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Acta Myol 30:48 Hoek RM, Ruuls SR, Murphy CA et al (2000) Down-regulation of the macrophage lineage through interaction with OX2 (CD200)

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The in vivo fluorescence in our experiment is maximally downregulated under Al toxicity

While the pro-inflammatory effect of microcrystalline UA is well-established 3,20 , there are several indications that soluble UA free of UA crystals has protective effects against inflammatory mechanisms and toxicity 50 with effects on macrophage polarisation towards the anti-inflammatory M2 phenotype 51