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The findings clarify the risk profile of GLP-1 receptor agonists amid earlier studies that had suggested a possible link between the drug class and optic nerve damage, according to the research team

Despite the dose discrepancy, the 1-month IGF-I can be seen to overlap between GHD and TS, likely reflecting differences in sensitivity to r-hGH, yet the polymorphisms associated with this change in serum IGF-I differ

Nausea is a direct drug effect caused by GLP-1 receptor activation in the brain and stomach

This approach potentially enables more efficient trial design through improved patient selection and outcome prediction, potentially reducing sample size requirements and trial duration