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AD: Alzheimers disease cAMP: cyclic adenosine monophosphate CSF: cerebrospinal fluid DPP-4: dipeptidyl-peptidase 4 DR: diabetic retinopathy GFAP: glial fibrillary acidic protein GLP-1: glucagon-like peptide 1 GLP-1R: glucagon-like peptide 1 receptor GLP-1RA: glucagon-like peptide 1 receptor agonist IIH: idiopathic intracranial hypertension IL-1beta: interleukin 1 beta NF-B: nuclear factor kappa B NO: nitric oxide PD: Parkinsons disease PINK1: protein phosphatase and tensin homolog-induced kinase 1 PKA: protein kinase A PPG: preproglucagon RGCs: retinal ganglion cells RPE: retinal pigment epithelium T2DM: type 2 diabetes mellitus TNF-alpha: tumor necrosis factor alpha VEGF: vascular endothelial growth factor Sohum S, AP, MF, MM, AR, RS, and Siddharth S: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writingoriginal draft

The scientific communitys skepticism was predictable but wrong

Those trials show consistent benefits for anemia, neuropathy, energy, and sometimes appetite when deficiency was the cause

Cederblad, and P.L