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IGF-1 elevation: Mean IGF-1 levels increased 1.5 to 3-fold above baseline and remained improved for up to 28 days after dosing

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Body size scalers and age factors were the most commonly identified covariates impacting busulfan PK in pediatric patients ( c standardized to 70-kg adult patient were 9.57 L/h and 28.2 L, respectively, which is consistent with previous studies ( To characterize developmental pharmacology, age-dependent physiological maturation functions were applied to describe changes in CL with age