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Vitamin B12, also known as cobalamin, is a water-soluble vitamin that plays a pivotal role in the functioning of the brain and nervous system , as well as the formation of red blood cells

Earlier studies showed that combining VEGFR and PDGFR inhibitors targeting endothelial cells and pericytes, respectively, improved the efficacy of anti-angiogenic therapy and reduced tumor growth in animal tumor models (Zonneville et al., 2018)

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