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Carnitine uptake by the liver depends on relatively high carnitine concentration in the blood, since carnitine enters the liver through OCTN2 (organic cation transporter 2), a carrier with high Km (Michaelis-Menten constant) for carnitine (Km = 5.6 mM: Christiansen and Bremer, 1976 ), thus the liver takes carnitine from the blood when its concentration is significantly rised

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The PIONEER-6 trial suggests cardiovascular benefit of oral semaglutide in patients with diabetes compared to placebo

Integrating GLP-1 receptor agonists into secondary prevention strategies into routine cardiometabolic care could yield significant population-level benefits, the researchers wrote