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Preclinical studies in Alzheimers mouse models, aged rats, and aged rhesus monkeys showed BDNF gene therapy prevented neuronal death, stimulated synaptic function, and improved memory

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In addition to education on proper treatment administration, the participants of the study also received dietary and physical activity counseling aimed towards achieving 150 minutes of physical activity per week and a 500 calorie deficit per day

Some protocols use divided doses (morning and evening), while others consolidate into a single morning injection on an empty stomach