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In AD mouse models, semaglutide increased the expression of SIRT1 and its downstream target, glucose transporter GLUT4, thereby enhancing glucose uptake and rectifying glycolytic deficits in the hippocampus ( 5.3 Direct neuroprotective and pro-survival pathways In addition to its anti-inflammatory and metabolic effects, semaglutide activates pathways that directly enhance neuronal survival and resilience

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Additionally, while some studies indicate that TGF1 inhibits proliferation and promotes differentiation 141,144 , other research suggests that TGF1 signaling enhances cellular proliferation in the crypt under irradiation 138

Older adults, sedentary patients, or individuals who lose weight very rapidly often do better with agents that produce more moderate weight loss, an area where emerging oral options may play an important role