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The consensus among diabetes specialists and GPs is that Mounjaro should be used as part of a comprehensive diabetes management strategy that prioritises lifestyle modificationsincluding a balanced diet, regular physical activity, and weight managementalongside pharmacological treatment

The dual mechanism provides advantages that a GLP-1-only drug cannot replicate

Animal models show that blood GLP-1 levels can vary during the day based on mealtimes, and this variation may be independent of the insulin variation (Dailey et al., Molecular Pathways About GLP-1 and Palatable Food Intake Evidence suggests a significant role of GLP-1 in modulating dopaminergic circuits and molecular synthesis of dopamine

It was conducted in a 1:1 ratio, using block randomization and stratified by IPTB severity