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Hu et al also found that early voluntary wheel running (VWR) 2 days after injury enhanced neurofunctional recovery and alleviated anxiety in mice, and this change was associated with reduced pro-inflammatory factor levels, increased anti-inflammatory factor levels, and reduced microglial activation [142]

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For example, a genetic predisposition may become unmasked in the presence of age-related malnutrition, or changes in neuronal homeostasis

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