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Ischemic symptoms may signal coronary heart disease and associated ventricular premature contractions that may warrant exercise stress testing

The tissue and cell disruption during processing (e.g., mixing, cutting, crushing, freezing/thawing, and high pressure treatment) makes native polyglutamyl folates accessible for endogenous conjugases (-glutamyl hydrolases) and results in the hydrolysis to monoglutamyl folates in vegetables (e.g., leeks, cauliflower, broccoli, spinach, soybeans, green beans, cowpea leaves, turnip, and carrot) and fruits (e.g., orange, papaya, sweet cherry, strawberry, and blackberry)

[28] This raises the possibility that this extracellular glutamate plays an "endocrine-like" role as part of a larger homeostatic system