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Mechanistic Insight Into Gut Microbiome-Mediated Neurodegeneration A clear pathophysiological link between immune and metabolic dysregulation and neurodegenerative disorders in the brain had been previously established (reviewed in Yan et al., 2020)

This mechanistic synergy, first characterised in foundational studies of GHRH and GHRP co-administration, provides the physiological and pharmacological rationale for the combination as a research tool for studying maximal physiological GH pulse generation and GH axis pharmacology

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Results GSTM2 was upregulated in hepatic tissues of mice fed HFD and MCDD The high-fat diet and methionine choline deficient diet were used to make hepatic steatosis