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The NJEM study shows that 14% of patients using 1mg retatrutide experienced nausea, while 18-36% with 4mg, 17-60% with 8 mg, and 45% with 12 mg had nausea compared to 11% in the placebo group

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However, the concurrent activation of the GLP-1 and GIP receptors creates a "glucose-protective" environment

Single-nucleus RNA-sequencing shows opposing effects of GIPR agonism and antagonism in the hindbrain, with antagonism, but not agonism, mimicking GLP-1R signalling and with GIPR antagonism and GLP-1R agonism both regulating gene programmes implicated in synaptic plasticity