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In the sensitivity analysis for two-year time lag, the result was similar to the main result

SHR rats originated at the Kyoto School of Medicine in 1963, where Okamoto mated an outbred Wistar Kyoto male with marked elevation of blood pressure to a female with slightly elevated blood pressure [24]

This means it simultaneously activates three different types of receptors: GLP-1 Receptor (Glucagon-Like Peptide-1) GIP Receptor (Glucose-Dependent Insulinotropic Polypeptide) Glucagon Receptor By targeting these three receptors, Retatrutide offers a multifaceted approach to managing blood glucose levels, enhancing insulin secretion, and potentially promoting weight loss