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By reducing the electric potential at the inner mitochondrial membrane below 200 mV (negative inside), it inhibits ATP synthase (complex V) and increases the accumulation of several-fold drugs inside the mitochondria, leading to alterations in processes in the mitochondria matrix [270]

Low levels of glutathione have been associated with increased susceptibility to infections in several diseases, such as AIDS, chronic obstructive pulmonary disease, cystic fibrosis, and influenza infection

It allows the peptide to work systemically with minimal risk

Many people experience ongoing mild symptoms throughout their lives, with occasional flares of more painful symptoms