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Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in mice

King NA, Caudwell PP, Hopkins M, Stubbs JR, Naslund E, Blundell JE

Shaking the vial creates mechanical stress that can break these chains apart (a process called shearing), destroying the molecule and rendering it ineffective for research

66 Metformin-induced SAM restriction significantly reduces H3K4me3 levels and prolongs lifespan in C