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Some contributors to PCOS include: A diet high in sugars and refined carbohydrates Chronic, low-grade inflammation Gut dysbiosis (imbalance in gut bacteria) Hormonal imbalances caused by excess male hormones

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Single and dual agonists The fundamental difference between these two molecules is that semaglutide is a GLP-1 agonist, i.e., it has a strong structural similarity (95%) with this hormone and specifically activates its receptor, while tirzepatide is a dual agonist, i.e., it has a hybrid structure that allows it to activate both GLP-1 and GIP receptors (Figure 2)

Our evaluation of publication bias produced conflicting findings