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Large meta-analyses and pooled data from randomized controlled trials demonstrate that GLP-1 receptor agonists do not increase the risk of depression, anxiety, suicidality, or other serious psychiatric adverse events compared to placebo

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Several dose levels have been explored as part of these studies: 1mg, 4mg, 8mg

For BMI above 40, comparison between GLP-1 therapy and bariatric surgery involves weighing multiple factors including health status, personal preferences, and long-term management considerations