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Low-Dose Naltrexone (LDN) works by temporarily blocking opioid receptors in the brain, triggering a rebound effect that leads to increased endorphin production

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In other cases, derivatives like oleuropein and other related polyphenols instead of HOTYR were found to be responsible for cytotoxic activity (71, 72)

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J Neurosci 2009;29:4351-5.ArticlePubMedPMC 98

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