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They encourage healthcare professionals and patients to discuss a range of factors, including potential benefits and harms, treatment costs, medication availability, existing health conditions, personal goals, life expectancy, and patient preferences

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Typical early lesions present as asymmetrical macules that may be uniformly pink or red and may have a faint light tan, brown, or grey pigmentation at the periphery

In other embodiments, the pH of the formulation or composition is about 6.0, about 6.5, about 7 or about 7.5