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In SURMOUNT 1, tirzepatide induced a mean BW reduction of 15.0%, 19.5% and 20.9% with 5 mg, 10 mg and 15 mg, respectively compared to 3.1% obtained with placebo at 72 weeks 34

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Therefore, the specific role of p53 in metabolic diseases must be correlated with a specific context

It exerts its anticancer effects by regulating various growth factors, protein kinases, inflammatory cytokines, and transcription factors, thereby inhibiting tumor proliferation and metastasis (228)