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Secondary structure restraints were used extensively, and model building was guided by evolutionary couplings analysis (Supplementary Fig

Common causes of hyperthyroidism include autoimmune conditions like Graves disease or thyroid nodules that increase hormone production

As described earlier, at the cellular level IGFBP-3 can act either as an oncogene or a tumor suppressor in different cancers

This might possibly be due to the engineered control circuits responding to the target product intermediate, limiting any improvement in production beyond initial control levels