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ACN acetonitrile the HPLC/MS system used was from Shimadzu (Kyoto, Japan), consisting of a CBM-20A communications bus module, LC-20AD pumps, SIL-20AC auto sampler, SPD-M20A diode array detector and LCMS-2010EV mass spectrometer

The reaction was terminated by the addition of 400 L phase A (0.1% trifluoracetic acid) before being fractionated into 1 mL volume by reverse-phase high-performance liquid chromatography (RP-HPLC, Waters 600 SimiPrep system) on a C18 column

Albuquerque BR, Heleno SA, Oliveira MBPP, Barros L, Ferreira ICFR (2021) Phenolic compounds: current industrial applications, limitations and future challenges

In the Phase 2 obesity trial (NCT04667377), mean body-weight loss at week 46 was dose-dependent, reaching approximately 14.9% at the highest 4.8-mg dose versus about 2.8% for placebo, per planned-treatment analysis