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It primarily affects sensory nerves, leading to progressive symptoms such as sensory loss, pain, and autonomic dysfunction [96,164]

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The underreported symptoms are leads that came from patients themselves, unprompted, and clinicians could potentially pay attention to them. Clinical trials generally identify the most dangerous side effects of drugs, says Lyle Ungar, professor in CIS and a co-author on the study

For instance, dry skin may develop fine lines earlier due to moisture loss, while oily skin might age more slowly but exhibit more visible expression lines, whilst sensitive skin can be prone to irritation