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For iatrogenic hypercortisolism (corticosteroid medication): gradual dose reduction under medical supervision is essential, as abrupt cessation can precipitate adrenal crisis

While the pro-inflammatory effect of microcrystalline UA is well-established 3,20 , there are several indications that soluble UA free of UA crystals has protective effects against inflammatory mechanisms and toxicity 50 with effects on macrophage polarisation towards the anti-inflammatory M2 phenotype 51

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