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Genes associated with Lm are enriched among the genes found to associated with the presence of COPD or degree of airflow obstruction in datasets from (a) Golpon et al .[6], (b) Spira et al .[9], (c) Wang et al .[10], and (d) Bhattacharya et al .[7]

They work through complementary mechanisms

All participants were confirmed to be experiencing a depressive episode using structured psychiatric interviews and rating scales like the HDRS-17 and MADRS

In addition, metformin also causes adverse side effects such as diarrhea and nausea which is experienced by 30% of patients, and some individuals experience, to a lesser extent, lactic acidosis