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Scientific American notes that glycogen is stored with water, which explains why some early weight loss is water weight rather than fat loss. Cleveland Clinic explains that starting with too large of a calorie deficit can lead to side effects such as fatigue, nausea, dehydration, constipation, headaches, and irritability. These symptoms are signals that energy intake may not be matching the bodys current needs

Nausea affects approximately 28% of users at higher doses during this period

Strategies such as eating smaller meals, drinking water throughout the day, and choosing lighter foods during the first few weeks can help reduce discomfort

This paper is part of a Supplement that was financially supported by the ERA