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After TBI, there is an activation of neuroinflammation response pathway mediated by microglia cells that were not initially damaged, and the activated microglial cells may promote the release of proinflammatory factors such as interleukin 1, tumor necrosis factor, nitric oxide, etc., (Kumar and Loane, 2012), inducing a progressive cycle of chronic inflammation (Borlongan et al., 2015)

Treatment of schistosomiasis in a patient allergic to praziquantel: a desensitization and treatment protocol

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This is why manufacturers often recommend storing the vials in a cool, dark place