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Symptoms of severe gastrointestinal (or GI) side effects can include the following, depending on which type of GI problem is involved: indigestion nausea and vomiting stool that is dark, sticky, or contains blood vomit that is similar to coffee grounds severe abdominal pain passing less gas, urine, or stool Factors that can increase the risk of serious GI side effects when taking meloxicam include: taking meloxicam long-term taking a high meloxicam dosage taking other medications that increase this risk, such as aspirin or warfarin (Jantoven) having a peptic ulcer or having had one in the past having active bleeding in your digestive tract or having had it in the past tobacco use or alcohol consumption being age 65 years or older having advanced liver disease What might help Before prescribing meloxicam, your doctor will evaluate your risk of these side effects

10.3390/nu13082660 260 LeeH

Upregulation of matrix metalloproteinase 9 (MMP9)/tissue inhibitor of metalloproteinase 1 (TIMP1) and MMP2/TIMP2 ratios may be involved in lipopolysaccharide-induced acute lung injury

Serious adverse events were balanced across groups