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In patients with inadequately controlled T2DM, tirzepatide improved glycaemic control and body weight more so than dulaglutide 0.75 mg, semaglutide 1 mg and insulin when used on its own or in combination with other medications

To what extent will the health economy respond by increasing supply to meet demand (including off-label) or adjusting prescribing practice patterns and guidelines to temper or regulate demand to focus on patients with clinically necessary indications

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Continuous use without breaks may reduce its long-term effectiveness and increase adaptation