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Mechanistic analysis revealed that AR directly promoted the transcription of miR-221, which in turn suppressed IGF-1 expression, leading to the inactivation of the MAPK pathway in DPCs and the PI3K/AKT pathway in DSCs

Per injection: 2 swabs 8 weeks (once daily): ~112 swabs 12 boxes Dosing Protocol A suggested daily titration approach based on common reference doses

Furthermore, in a paraquat-induced fibrosis model, Xuebijing injection, a traditional Chinese medicine compound, corrected elevated levels of L-valine, glycine, and L-tryptophan, indicating its antifibrotic potential may be related to rebalancing amino acid metabolic disturbances [165]