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A transformation of the non-parametric MannWhitney statistic [22] was used to describe the overlap in each study outcome measure between separate baseline BSA groups (low vs medium vs high BSA) to determine whether each measure in a randomly selected patient in one BSA group exceeded that in a patient in a different BSA group

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134 In addition, a clinically significant DDI was reported in a Phase I study of ALRN-6924, an analog of ATSP-7041 and an inhibitor of OATP1B3

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