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Peroxidase-like active nanomedicine with dual glutathione depletion property to restore oxaliplatin chemosensitivity and promote programmed cell death

At the same time, most small-molecule and biologic drugs distribute widely in the circulation, while only a limited and often heterogeneous fraction reaches the tumor, resulting in insufficient and uneven local exposure [7]

[7] [8] It turned out that this effect was due to a small peptide factor that behaved similarly to the synthetic peptide glycyl-L-histidyl-L-lysine (GHK)

While this has not been confirmed in humans, it is considered a relative contraindication by most practitioners