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IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a synthetic analog of human insulin-like growth factor-1 (IGF-1) with structural modifications that distinguish it from the endogenous peptide

In accordance, newborns with mutations in the GH Releasing Hormone Receptor (GHRHR) gene resulting in an isolated GH deficiency (GHD) phenotype was associated with normal birth weight in one cohort (53) and slightly subnormal birth weight in another (54)

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