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Effect of mAChR Antagonists In Vivo During the Intravenous Glucose Tolerance Test on Glucose Homeostasis As expected, chronic metformin treatment reduced hyperglycemia during intravenous glucose tolerance test (ivGTT), as shown in Figure 1A

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Especially notable are oxidative stress and inflammatory responses, which are highly active in T2DM patients, leading to bone cell damage and apoptosis, thus exacerbating osteoporosis