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Studies reviewed by Hector and Burton involving 91 patients with hypovitaminosis B12 who exhibited neuropsychiatric symptoms found that clinical improvement was achieved in many individuals through vitamin B12 replacement therapy (74)

Certain brain disorders have accelerated neuro-degeneration that give us clues

The interaction between vitamin B12 and Apolipoprotein E (APOE) significantly influences cognitive function in older adults, with APOE carriers showing a stronger positive association between vitamin B12 levels and cognitive performance compared to noncarriers [61]