wegovy glp-1 agonist Novo's becomes first drug approved for MASH US approves first GLP-1 pill

PLoS ONE 9(6):e101005 De Marinis YZ, Salehi A, Ward CE, Zhang Q, Abdulkader F, Bengtsson M et al (2010) GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis

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Goal: Maintain testicular function and support recovery Approach: Begin HCG 1500-2000 IU every other day during final 2 weeks of cycle Continue for 2-3 weeks after last steroid dose Transition to SERM (clomiphene 50mg daily for 2 weeks, then 25mg for 2 weeks) Discontinue HCG when starting SERM Monitoring: Blood work at 4 weeks post-cycle Verify testosterone recovery before discontinuing SERM For additional context on recovery protocols, our guide on peptides versus steroids discusses differences in recovery requirements