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Optimized production of insulin variant, a recombinant platelet aggregation inhibitor, by high cell-density fermentation of recombinant Escherichia coli

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The upregulation of type A monoamine oxidase (MAOA) and the downregulation of serotonin (5-hydroxytryptamine, 5-HT) and NE levels in the brain are considered to be the primary etiological factors underlying depression