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Lugovic-Mihic, L

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In addition to these well-characterized metabolic activities, a number of novel biologic functions of GLP-1 have been shown to occur in animals and include: Regulation of -cell genes involved in glucose sensing and insulin biosynthesis and secretion Expansion of -cell mass through the proliferation and neogenesis of pancreatic cells Potentiation of glucose uptake in peripheral tissues

In this context, the observed upregulation of MPC2 expression in our study holds pivotal significance: MPC2 acts as a critical node linking glycolysis to mitochondrial energy metabolism by transporting cytosolic pyruvate into mitochondria for oxidation