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Although GLP-1RA therapy facilitates mobility through weight loss, particularly in older adults, maintaining exercise and physical activity can be challenging due to side effects and fatigue
A plateau may reflect several overlapping factors: Lower calorie needs at a lower body weight Adaptive metabolic changes during weight loss Decreased daily movement or step count Loss of lean muscle mass Inconsistent protein intake Constipation or water retention masking fat loss Sleep disruption or stress hormones Medications that promote weight gain or fluid retention Undiagnosed thyroid, hormone, or metabolic issues Normal transition from active loss into maintenance The correct response depends on the cause
[DOI] [PMC free article] [PubMed] [Google Scholar] 95.Ko G.J., Obi Y., Tortorici A.R., Kalantar-Zadeh K
By targeting the NNMT enzyme, it helps the body flip from fat storage to fat-burning mode, while simultaneously boosting NAD+ and activating SIRT1the cellular guardian of youth
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