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BPC-157 upregulates survival genes (Akt1, KRAS, Src, Foxo1), reduces inflammatory mediators (IL-6, TNF-, NOS2, NFB), scavenges reactive oxygen species through its four carboxylic groups, activates vascular bypass pathways, and maintains blood flow despite vessel occlusion

In contrast to the mouse ear swelling test and guinea-pig assays, activity here is measured as a function of events occurring during the induction, rather than elicitation, phase of contact sensitization

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IGF1 shapes macrophage activation in response to immunometabolic challenge