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Once-weekly semaglutide in persons with obesity and knee osteoarthritis
GLP-1 (glucagon-like peptide-1) helps regulate blood sugar, reduce appetite, and increase feelings of fullness, making it easier for patients to manage their weight
It has a short circulating half-life of approximately seven minutes due to rapid degradation by dipeptidyl peptidase IV (DPP-IV) ( Importantly, GLP-2R is not expressed on enterocytes
The guidelines warn, however, that GLP-1 receptor agonist therapy is not indicated for all patients and should be used with caution in patients with a history of significant gastrointestinal disease, such as a diagnosis of gastroparesis, due to a possible exacerbation of the condition with incretin mimetic therapy
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