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Oxalate at physiological urine concentrations induces oxidative injury in renal epithelial cells: effect of alpha-tocopherol and ascorbic acid

The extracellular citrulline autoantigen present in the joints of RA patients is mainly derived from the increased NET, which can cause the inflammatory response of synovial fibroblasts in patients and release a series of inflammatory mediators (such as pro-inflammatory cytokines, adhesion molecules and chemokines) to drive the progression of RA (205)

At standard doses (12 mg/day), copper loading from GHK-Cu is minimal and unlikely to be clinically significant