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197 VeysL.VandenabeeleM.Ortuo-LizarnI.BaekelandtV.CuencaN.MoonsL.et al (2019)

Additionally, it indirectly reduces A2E photooxidation, lowers methylglyoxal levels, and inhibits the upregulation of the receptor for advanced end glycation products [245, 248]

As yet, the relationships between enzymatic activity and mutation of MTHFR have been reported in general healthy and mental retardation populations as well as in animals, no studies have been found in clinical test of MTHFR activity in psychiatric patients 88,89,90