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Most of these conditions are painful inflammation, fluid accumulation, or require direct medication delivery to the joint or bursa

The complete chemical structure of the molecule was determined by Dorothy Hodgkin based on crystallographic data and published in 1955 [147] and 1956, [148] for which, and for other crystallographic analyses, she was awarded the Nobel Prize in Chemistry in 1964

Having said that some patients do get a paradoxical response to B12 and present with fatigue, headaches, and flu-like symptoms

They are effective in treating cobalamin deficiency caused by IBD, EPI, chronic enteropathy, and other conditions