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Our study also indicated that the effects of Semaglutide on increasing miR-5120 expression and decreasing ABHD6 expression were abolished after the inhibition of GLP-1R in Hepa 16 hepatocytes by GLP-1R siRNA-1 (Figure 6AC)

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ChREBP is a key transcription factor for enzymes in the fructolysis, glycolysis, gluconeogenesis, and DNL pathways ( 2.3 Oxidative stress A number of factors contribute to the occurrence of multiple hits, with oxidative stress being considered the primary cause of liver injury and disease progression in NAFLD (Zhang et al., 2019)