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Tirzepatide demonstrates superior outcomes in: - Normoglycemia restoration - Glycemic control - Weight reduction - Insulin sensitivity Implication for Practice These findings suggest a potential shift in therapeutic strategy for patients with obesity and prediabetesprioritizing interventions that not only reduce weight but actively modify disease trajectory toward type 2 diabetes prevention

Loss of the neurotransmitter dopamine, due to the degeneration of dopaminergic neurons in the midbrain underlies the pathophysiology of the motor dysfunction

doi:10.1074/jbc.M109.091116 221

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