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Devnani points to the following culprits that can aggravate RLS: Over-the-counter antihistamines, cold, and allergy medications, including Benadryl, Tylenol PM, or NyQuil Antidepressants and selective serotonin-reuptake inhibitors (SSRIs), like fluoxetine and sertraline Antinausea drugs like Antivert, Phenergan, and Bonine Consult with your doctor before taking any medications to make sure they arent triggering symptoms, and stick to recommended dosing, Cline says

The papers data on suppressed endogenous glucose production and reduced expression of Pcx and Pepck1 (the master regulators of hepatic gluconeogenesis) is consistent with central nervous system mediation of liver effects

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