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they may originate from mature melanocytes residing in the basal cell layer of the epithelium that have undergone some cytogenetic alterations culminating in their dedifferentiation into naevomelanocytes or they may originate from stem/progenitor melanocytes that have undergone cytogenetic alteration in the process of replacing mature melanocytes in the epithelium lost to mechanical, thermal, or chemical injury or as a result of apoptotic processes

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Both drugs mimic the hormone GLP-1, which helps regulate blood sugar and appetite, but tirzepatide also targets another pathway called glucose-dependent insulinotropic polypeptide (GIP)