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doi: 10.1016/j.mam.2004.06.003 24

These side effects might have contributed to the less-than-ideal satisfaction rate

You start at 2.5 mg weekly and increase by 2.5 mg every 4 weeks until reaching an effective dose, usually 7.5 to 15 mg weekly

The transformation of the catechol group into o-quinones is a chemical reaction involving the oxidation of the hydroxyl group at the ortho position of the phenolic ring [163]